HCID 19935831, compound → HCID 19935865, compound

HRID 37549Notes

Reaction equation

HRID 37549 reaction equation
[SH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]2.Cl.[F:15][CH:16]([F:33])[CH2:17][N:18]1[CH2:22][CH2:21][C:20]([C:25]2[CH:30]=[C:29](F)[CH:28]=[C:27]([F:32])[CH:26]=2)([O:23][CH3:24])[CH2:19]1>>[F:32][C:27]1[CH:28]=[C:29]([S:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]3)[CH:30]=[C:25]([C:20]2([O:23][CH3:24])[CH2:21][CH2:22][N:18]([CH2:17][CH:16]([F:15])[F:33])[CH2:19]2)[CH:26]=1

Participants

3

Reactant 2

HCID 19935831HCID 19935831, compoundHCID 224137591-Methyl-6-sulfanyl-1,2,3,4-tetrahydroquinolin-2-one

Product 1

HCID 19935865HCID 19935865, compoundYield 51%

Procedure

Using an analogous procedure to that described in Example 6, 6-mercapto-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 1-(2,2-difluoroethyl)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine hydrochloride to give 3-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-1-(2,2-difluoroethyl)-3-methoxypyrrolidine as a gum in 51% yield.

Sources & evidence

ORD record
ord-19ed25f2243a450da9ba031dd1f5acc3
Source dataset
uspto-grants-1995_05
Patent number
US05420298

Reaction notes

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