HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 19935831, compound → HCID 19935865, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 19935831 | HCID 19935831 | — |
| Reactant | 1-Methyl-6-sulfanyl-1,2,3,4-tetrahydroquinolin-2-one | HCID 22413759 | — |
| Product | HCID 19935865 | HCID 19935865 | 51% |
Reaction Steps
Using an analogous procedure to that described in Example 6, 6-mercapto-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 1-(2,2-difluoroethyl)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine hydrochloride to give 3-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-1-(2,2-difluoroethyl)-3-methoxypyrrolidine as a gum in 51% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420298 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-19ed25f2243a450da9ba031dd1f5acc3 |
| Source note | uspto-grants-1995_05 |