反应详情

温度

160 °C

A mixture of 1,2-diaminobenzene (0.67 g) and 4-[3-(4-phenylpiperazin-1-yl)propoxy]benzaldehyde (Example A) (2.00 g) in nitrobenzene (65 mL) is stirred for 16 hours at 160° C. The solvent is distilled off under high vacuum and the resulting solid is purified by medium pressure liquid chromatography (MPLC) on silica gel eluting with 200:8:1 dichloromethane: ethanol:0.880 aqueous ammonia to give 0.97 g of the title compound as a tan solid; mp 240°-244° C.

1. distillationThe solvent is distilled off under high vacuum
2. customthe resulting solid is purified by medium pressure liquid chromatography (MPLC) on silica gel eluting with 200:8:1 dichloromethane