HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 375527Generated: October 27, 2026
O-Phenylenediamine → HCID 9909614, compound
https://huagongshe.com/reaction/375527
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | Benzaldehyde, 4-(3-(4-phenyl-1-piperazinyl)propoxy)- | HCID 55234 | — |
| Solvent | Nitrobenzene | HCID 7416 | — |
| Product | Ammonia | HCID 222 | — |
| Product | HCID 9909614 | HCID 9909614 | 75.9% |
Reaction Steps
A mixture of 1,2-diaminobenzene (0.67 g) and 4-[3-(4-phenylpiperazin-1-yl)propoxy]benzaldehyde (Example A) (2.00 g) in nitrobenzene (65 mL) is stirred for 16 hours at 160° C. The solvent is distilled off under high vacuum and the resulting solid is purified by medium pressure liquid chromatography (MPLC) on silica gel eluting with 200:8:1 dichloromethane: ethanol:0.880 aqueous ammonia to give 0.97 g of the title compound as a tan solid; mp 240°-244° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05486517 |
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| Source dataset | uspto-grants-1996_01 |
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| ORD ID | ord-e796f27f381b48369ecc4b083c90b0cf |
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| Source note | uspto-grants-1996_01 |
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