HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetonitrile → 1-(Cyanomethyl)-3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | HCID 19935823 | HCID 19935823 | — |
| Product | 1-(Cyanomethyl)-3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine | HCID 19935811 | 45% |
Reaction Steps
Using an analogous procedure to that described in Example 3, 3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine was reacted with 2-chloroacetonitrile to give 1-(cyanomethyl)-3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine in 45% yield, m.p. 76°-77° C. (recrystallised from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420298 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-988c8deec7924439a3156a6a3fc332c9 |
| Source note | uspto-grants-1995_05 |