関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Phenylpiperazine | HCID 7096 | — |
| 反応物 | 3-Butynyl p-toluenesulfonate | HCID 272020 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(But-3-yn-1-yl)-4-phenylpiperazine | HCID 18993038 | 78.9% |
反応手順
A mixture of but-3-ynyl-p-toluenesulfonate (8.97 g), 1-phenylpiperazine (6.49 g) and sodium bicarbonate (3.7 g) in dimethylformamide (100 mL) is stirred at 80° C. for 14 hours. The solvent is evaporated and the residue dissolved in dichloromethane, washed with water and dried over MgSO4. The solution is filtered through silica gel and the product eluted with 10% ethyl acetate/hexanes to give 6.76 g of the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05486517 |
|---|
| 出典データセット | uspto-grants-1996_01 |
|---|
| ORD ID | ord-1b1257d60573427cb265f52a07432601 |
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| 出典メモ | uspto-grants-1996_01 |
|---|
