反应详情

温度

80 °C

A mixture of but-3-ynyl-p-toluenesulfonate (8.97 g), 1-phenylpiperazine (6.49 g) and sodium bicarbonate (3.7 g) in dimethylformamide (100 mL) is stirred at 80° C. for 14 hours. The solvent is evaporated and the residue dissolved in dichloromethane, washed with water and dried over MgSO4. The solution is filtered through silica gel and the product eluted with 10% ethyl acetate/hexanes to give 6.76 g of the title compound as a white solid.

1. customThe solvent is evaporated
2. dissolutionthe residue dissolved in dichloromethane
3. washwashed with water
4. dry with materialdried over MgSO4
5. filtrationThe solution is filtered through silica gel
6. washthe product eluted with 10% ethyl acetate/hexanes