HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(1h-Benzimidazol-2-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-(1H-benzo[d]imidazol-2-yl)benzoate | HCID 2328806 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(1h-Benzimidazol-2-yl)benzoic acid | HCID 759419 | 101.5% |
Reaction Steps
Methyl 4-(1H-benzimidazol-2-yl)benzoate (Step A) (2.63 g) is stirred in THF (50 mL) and water (10 mL) with sodium hydroxide (2.08 g) at reflux for 4 hours. The solvent is evaporated and the residue treated with 2N hydrochloric acid (100 mL). The resulting suspension is collected, washed with methanol/ethyl acetate and dried to give 2.52 g of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05486517 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-d6321a9b9f97403a91e05f81e8a9d4d6 |
| Source note | uspto-grants-1996_01 |