反应详情

Methyl 4-(1H-benzimidazol-2-yl)benzoate (Step A) (2.63 g) is stirred in THF (50 mL) and water (10 mL) with sodium hydroxide (2.08 g) at reflux for 4 hours. The solvent is evaporated and the residue treated with 2N hydrochloric acid (100 mL). The resulting suspension is collected, washed with methanol/ethyl acetate and dried to give 2.52 g of the title compound as a white solid.

1. customThe solvent is evaporated
2. additionthe residue treated with 2N hydrochloric acid (100 mL)
3. customThe resulting suspension is collected
4. washwashed with methanol/ethyl acetate
5. customdried