Hydrochloric Acid → HCID 18993315, compound

HRID 375573Notes

Reaction equation

HRID 375573 reaction equation
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(O)[CH:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:21]>>[ClH:21].[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18993323HCID 18993323, compound

Product 1

HCID 18993315HCID 18993315, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 3-(diphenylhydroxymethyl)piperidine (801 mg, 3.0 mmol) and 2M hydrochloric acid (12 ml) was stirred at 100° C. for 2 hours and evaporated. The residue was triturated with toluene and recrystallised from methanol to give the title compound (730 mg) as a colourless solid, m.p. 236°-237° C.

Workup

  1. customevaporated
  2. customThe residue was triturated with toluene
  3. customrecrystallised from methanol

Sources & evidence

ORD record
ord-a453694305de47848a80fe79771bb561
Source dataset
uspto-grants-1996_01
Patent number
US05486527

Reaction notes

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