Hydroxyamine hydrochloride → HCID 85050946, compound

HRID 37563Notes

Reaction equation

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:12]=[C:13]([C:18]3([O:28][CH3:29])[CH2:22][CH2:21][N:20]([CH2:23][C:24]([F:27])([F:26])[F:25])[CH2:19]3)[CH:14]=[C:15]([F:17])[CH:16]=2)=[CH:6][CH:5]=1)(=O)[CH3:2].Cl.[NH2:31][OH:32]>>[F:17][C:15]1[CH:16]=[C:11]([S:10][C:7]2[CH:6]=[CH:5][C:4]([C:1](=[N:31][OH:32])[CH3:2])=[CH:9][CH:8]=2)[CH:12]=[C:13]([C:18]2([O:28][CH3:29])[CH2:22][CH2:21][N:20]([CH2:23][C:24]([F:25])([F:27])[F:26])[CH2:19]2)[CH:14]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 19935864HCID 19935864, compound

Product 1

HCID 85050946HCID 85050946, compoundYield 81%

Procedure

Using an analogous procedure to that described in Example 27, 3-[3-(4-acetylphenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine was reacted with hydroxylamine hydrochloride to give 3-{5-fluoro-3-[4-(1-hydroxyiminoethyl)phenylthio]phenyl}-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine as a gum in 81% yield.

Sources & evidence

ORD record: ord-23bd66af982f4a1592049b4404d0792e
Source dataset: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05420298

Reaction notes

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