HCID 54015813, compound → HCID 54230735, compound

HRID 375738Notes

Reaction equation

HRID 375738 reaction equation
[N+:1]([C:4]1[CH:24]=[CH:23][C:7]([CH2:8][O:9][C:10]([O:12][C@@H:13]([CH3:22])[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]>FC(F)(F)C(O)=O>[N+:1]([C:4]1[CH:24]=[CH:23][C:7]([CH2:8][O:9][C:10]([O:12][C@@H:13]([CH3:22])[CH2:14][C:15]([OH:17])=[O:16])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 54015813HCID 54015813, compound

Product 1

HCID 54230735HCID 54230735, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 5.10 g of tert-butyl (S)-3-(4-nitrobenzyloxycarbonyloxy)-butyrate in 20 ml of trifluoroacetic acid was stirred at 0° C. for 90 minutes. The solvent was evaporated in vacuo, and the residue was crystallized from methylene chloride/hexane to yield 3.28 g of (S)-3-(4-nitrobenzyloxycarbonyloxy)-butyric acid as white crystals of m.p. 78°-81° C.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was crystallized from methylene chloride/hexane

Sources & evidence

ORD record
ord-f65860c44952454d8aba94ff269f87a1
Source dataset
uspto-grants-1996_01
Patent number
US05486466

Reaction notes

Loading…