Formaldehyde → HCID 18991206, compound

HRID 375779Notes

Reaction equation

HRID 375779 reaction equation
[C:1]([C:5]1[CH:6]=[C:7](Br)[CH:8]=[C:9]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:10]=1[O:11][Si:12]([CH3:15])([CH3:14])[CH3:13])([CH3:4])([CH3:3])[CH3:2].[CH2:21]=[O:22]>>[C:1]([C:5]1[CH:6]=[C:7]([CH:8]=[C:9]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:10]=1[O:11][Si:12]([CH3:15])([CH3:14])[CH3:13])[CH:21]=[O:22])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 10882840(2,6-Di-tert-butyl-4-bromophenoxy)trimethylsilane

Product 1

HCID 18991206HCID 18991206, compoundYield 45%

Procedure

By proceeding as indicated in the procedure of Preparation VII above, starting with 10 mmol of 3,5-di-t-butyl-4-trimethylsilyloxy-bromobenzene and 15 mmol of HCHO (in the protected form of H2C(OCH3)2), one obtains (yield: 45%) 3,5-di-t-butyl-4-trimethylsilyloxy-benzaldehyde, followed by the expected product, 3,5-di-t-butyl-4-hydroxybenzaldehyde.

Sources & evidence

ORD record
ord-af45e39ef51a45c29ee659f8040b5eec
Source dataset
uspto-grants-1996_01
Patent number
US05487893

Reaction notes

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