HCID 18914706, compound → HCID 15296673, compound

HRID 375843Notes

Reaction equation

HRID 375843 reaction equation
[CH2:1]([N:3]([CH2:28][CH3:29])[CH2:4][CH2:5][S:6]([CH2:9][CH:10]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:11]([O:13]CC1C=CC=CC=1)=[O:12])(=[O:8])=[O:7])[CH3:2]>C(O)C.[Pd]>[CH2:28]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][S:6]([CH2:9][CH:10]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:11]([OH:13])=[O:12])(=[O:8])=[O:7])[CH3:29]

Participants

4

Reactant 1

HCID 18914706HCID 18914706, compound

Product 1

HCID 15296673HCID 15296673, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The title compound of Step 16 (167 mg, 0.4 mmol) is debenzylated in ethanol with 5psi H2 at room temperature for 1.5 hours using 4% Pd/C catalyst. After filtering, the solvent is stripped off to give the title compound.

Workup

  1. filtrationAfter filtering

Sources & evidence

ORD record
ord-6073358a46844f67b2197e096a8fc42f
Source dataset
uspto-grants-1996_01
Patent number
US05488066

Reaction notes

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