HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-(1-phenylmethylpyrazol-5-yl) anthranilic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Iodobenzoic acid | HCID 6941 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Benzyl-1H-pyrazol-5-amine | HCID 77061 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(1-phenylmethylpyrazol-5-yl) anthranilic acid | HCID 54572611 | — |
Reaction Steps
A mixture of 2-iodobenzoic acid (14 g, 0.057 mol), 5-amino-1-phenylmethylpyrazole (9.8 g, 0.057 mol), DMF (140 ml), potassium carbonate (8.3 g) and Cu(OAc)2 (0.1 g) was refluxed for about 2 days. The reaction mixture was poured into water, acidified with acetic acid to a pH of 5 and then the solid which formed was collected by filtration, washed with water, then ether and then was dried to afford N-(1-phenylmethylpyrazol-5-yl) anthranilic acid, m.p. 190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05488055 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-93864020695544eda823cc3b6301a491 |
| Source note | uspto-grants-1996_01 |