反应详情

A mixture of 2-iodobenzoic acid (14 g, 0.057 mol), 5-amino-1-phenylmethylpyrazole (9.8 g, 0.057 mol), DMF (140 ml), potassium carbonate (8.3 g) and Cu(OAc)2 (0.1 g) was refluxed for about 2 days. The reaction mixture was poured into water, acidified with acetic acid to a pH of 5 and then the solid which formed was collected by filtration, washed with water, then ether and then was dried to afford N-(1-phenylmethylpyrazol-5-yl) anthranilic acid, m.p. 190° C.

1. temperaturewas refluxed for about 2 days
2. customthe solid which formed
3. filtrationwas collected by filtration
4. washwashed with water
5. dry with materialether and then was dried