反应详情

温度

60 °C

To 2-phenoxybenzaldehyde (4.96 g, 0,025 mole) were added anhydrous methanol (50 ml) and hydroxylamine hydrochloride (2.08 g, 0.03 mole), and the mixture was stirred at 60° C. for 3 hours. After completion of the reaction, water (200 ml) was added to the reaction mixture, which was extracted with methylene chloride and dried over magnesium sulfate. The crude product obtained by concentration under reduced pressure was purified by silica gel chromatography (ethyl acetate/n-hexane) to obtain 2-phenoxybenzaldoxime (3.95 g, yield: 74.1%) as a colorless oil.

1. additionwas added to the reaction mixture, which
2. extractionwas extracted with methylene chloride
3. dry with materialdried over magnesium sulfate
4. customThe crude product obtained by concentration under reduced pressure
5. customwas purified by silica gel chromatography (ethyl acetate/n-hexane)