反应详情

温度

0 °C

A mixture of 4.2 g of the product of Step C, 40 ml of tetrahydrofuran and 2.7 g of N-bromo-succinimide was cooled to 0° C. and stirred for one hour at this temperature, then brought to dryness. The residue was chromatographed on silica, eluting with a hexane--ethyl acetate mixture (8-2) to obtain 1.9 g of the expected product. Thin layer chromatography; Rf=0.28 [eluant: hexane-- ethyl acetate (8-2)].

1. customThe residue was chromatographed on silica
2. washeluting with a hexane