反应详情

温度

50 °C

A mixture of 3.1 g of the product of Step E and 30 ml of dimethylformamide dimethyl acetal was heated to 50° C. and after 5 hours at this temperature, the mixture was allowed to return to 20° to 25° C. The mixture was stirred for 16 hours and then was brought to dryness. The residue was chromatographed on silica, eluting with a hexane--ethyl acetate mixture (8-2) to obtain after evaporation of the solvents, 2 g of the desired product. Thin layer chromatography; Rf=0.15 [eluant: hexane--ethyl acetate (8-2)].

1. customto return to 20° to 25° C
2. customThe residue was chromatographed on silica
3. washeluting with a hexane
4. customethyl acetate mixture (8-2) to obtain
5. customafter evaporation of the solvents, 2 g of the desired product