反应详情

1 g (2.17 mmol) of 4-(1-acetylpiperidin-4-yl)-5-diisopropylphosphono-2-formylamino-pent-3-enoic acid ethyl ester is heated under reflux in 20 ml of 6N hydrochloric acid for 8 hours. After concentration by evaporation, the residue is dissolved in 25 ml of ethanol. 3 ml of propylene oxide are then added, the mixture is stirred for 2 hours at room temperature and for one hour with ice cooling, and then the suspension that has formed is filtered off with suction. 2-amino-4-(piperidin-4-yl)-5-phosphono-pent-3-enoic acid having a melting point of 212° (decomp.) is obtained.

1. concentrationAfter concentration
2. customby evaporation
3. dissolutionthe residue is dissolved in 25 ml of ethanol
4. addition3 ml of propylene oxide are then added
5. customthe suspension that has formed
6. filtrationis filtered off with suction