HCID 54417787, compound → HCID 53845063, compound

HRID 376175Notes

Reaction equation

HRID 376175 reaction equation
[NH2:1][CH:2]([CH:8]=[C:9]([CH2:15][P:16]([OH:19])([OH:18])=[O:17])[CH2:10][CH2:11][CH2:12][CH2:13][OH:14])[C:3]([O:5]CC)=[O:4]>O>[NH2:1][CH:2]([CH:8]=[C:9]([CH2:15][P:16]([OH:19])([OH:18])=[O:17])[CH2:10][CH2:11][CH2:12][CH2:13][OH:14])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 1

HCID 54417787HCID 54417787, compound

Product 1

HCID 53845063HCID 53845063, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.0 g (3.4 mmol) ethyl 2-amino-4-phosphonomethyl-8-hydroxy-oct-3-enoate (Example 20) in 10 ml of water are refluxed, while stirring, for 48 hours. The reaction mixture is evaporated to dryness yielding after drying 0.58 g (64% yield) of 2-amino-4-phosphonomethyl-8-hydroxy-oct-3-enoic acid, m.p. 152°-155°.

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. customyielding

Sources & evidence

ORD record
ord-a9be663c0e0b4569866867371aa96807
Source dataset
uspto-grants-1996_01
Patent number
US05488140

Reaction notes

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