Benzyl Bromide → HCID 19360887, compound

HRID 376204Notes

Reaction equation

HRID 376204 reaction equation
[F:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4][C:3]=1[C:13]([OH:15])=[O:14].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[OH-].[K+]>>[F:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:9][CH:10]=2)[CH2:5][CH2:4][C:3]=1[C:13]([OH:15])=[O:14]

Participants

4

Reactant 3

HCID 7498Benzyl BromideHCID 14797Potassium HydroxideHCID 19360897HCID 19360897, compound

Product 1

HCID 19360887HCID 19360887, compound

Procedure

That is, for example, 3,4-dihydro-1-fluoro-6-hydroxy-2-naphthalenecarboxylic acid (i) is reacted with benzyl bromide in the presence of a base such as potassium hydroxide, to obtain 3,4-dihydro-1-fluoro-6-benzyloxy-2-naphthalenecarboxylic acid (ii).

Sources & evidence

ORD record
ord-077e1e14142744b1bbb70376f2994a87
Source dataset
uspto-grants-2000_02
Patent number
US06019911

Reaction notes

Loading…