反应详情

A mixture of resin-supported triphenylphosphine (3 mmol triphenylphosphine/g resin; 58.6 g) and N-(4-benzyloxy-phenyl)-2,2,2-trifluoro-acetamide (20.8 g) in carbon tetrachloride (800 ml) was heated to reflux under nitrogen for 18 h. The mixture was allowed to cool then filtered, washing the resin with dichloromethane (1 l) and ether (1 l). The organics were concentrated in vacuo to give the title compound as a yellow solid (20.7 g).

1. temperaturewas heated
2. temperatureto reflux under nitrogen for 18 h
3. temperatureto cool
4. filtrationthen filtered
5. washwashing the resin with dichloromethane (1 l) and ether (1 l)
6. concentrationThe organics were concentrated in vacuo