Hydrochloric Acid → HCID 69830381, compound

Participants

Reaction Steps

A solution of 3-{tert-butoxycarbonyl-[2-(cyclopropylmethoxy)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-amino}[2S,3S]-2-phenylpiperidine-1-carboxylic acid tertbutyl ester (101 mg, 0.15 mmole) in 4M-hydrogen chloride in dioxan (5 ml) was kept at 44° for 3.25 h and then evaporated. The residue was triturated with ethanol to give the title compound as a white solid (66 mg), mass spectrum (thermospray +ve) m/e 473 (MH+). RF 0.5 (100: 8:1 dichloromethane: ethanol: ammonia).

Provenance & Evidence