Hydrochloric Acid → HCID 69830381, compound

HRID 376273Notes

Reaction equation

HRID 376273 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([N:14](C(OC(C)(C)C)=O)[CH2:15][C:16]2[CH:21]=[C:20]([N:22]3[C:26]([C:27]([F:30])([F:29])[F:28])=[N:25][N:24]=[N:23]3)[CH:19]=[CH:18][C:17]=2[O:31][CH2:32][CH:33]2[CH2:35][CH2:34]2)[C@@H:9]1[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)=O)(C)(C)C.[ClH:49]>O1CCOCC1>[ClH:49].[ClH:49].[CH:33]1([CH2:32][O:31][C:17]2[CH:18]=[CH:19][C:20]([N:22]3[C:26]([C:27]([F:28])([F:30])[F:29])=[N:25][N:24]=[N:23]3)=[CH:21][C:16]=2[CH2:15][NH:14][C@H:10]2[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]2[C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[CH2:35][CH2:34]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57146641HCID 57146641, compound

Product 1

HCID 69830381HCID 69830381, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-{tert-butoxycarbonyl-[2-(cyclopropylmethoxy)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-amino}[2S,3S]-2-phenylpiperidine-1-carboxylic acid tertbutyl ester (101 mg, 0.15 mmole) in 4M-hydrogen chloride in dioxan (5 ml) was kept at 44° for 3.25 h and then evaporated. The residue was triturated with ethanol to give the title compound as a white solid (66 mg), mass spectrum (thermospray +ve) m/e 473 (MH+). RF 0.5 (100: 8:1 dichloromethane: ethanol: ammonia).

Workup

  1. customevaporated
  2. customThe residue was triturated with ethanol

Sources & evidence

ORD record
ord-c22d4c9658144547a064a99eb77717af
Source dataset
uspto-grants-2000_02
Patent number
US06020346

Reaction notes

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