HCID 19361734, compound → HCID 19361749, compound

HRID 376292Notes

Reaction equation

HRID 376292 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([CH3:14])=[CH2:13])[N:7]=1>[Pd].CO>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]([CH3:14])[CH3:13])[N:7]=1

Participants

4

Reactant 1

HCID 19361734HCID 19361734, compound

Product 1

HCID 19361749HCID 19361749, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 0.60 g of 2-[1,3]dioxolan-2-yl-6-isopropenylpyridine (3.15 mmol) and 0.10 g of 10% palladium on carbon, in 7 ml of methanol is stirred vigorously under a low hydrogen pressure for 4 hours at room temperature. The solid is removed by filtration on celite and then the methanol is evaporated off. The title product is isolated by chromatography on a silica column (eluent: chloroform/ethyl acetate; 97:3). 0.40 g of a pale yellow oil is obtained.

Workup

  1. customThe solid is removed by filtration on celite
  2. customthe methanol is evaporated off

Sources & evidence

ORD record
ord-879547c126b140ef9d85adf60af2f9b0
Source dataset
uspto-grants-2000_02
Patent number
US06020345

Reaction notes

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