反应详情

1 g of 6-[1,3]dioxolan-2-yl-pyridine-2-carbaldehyde (5.58 mmol), 1.10 g of tosylmethyl isocyanate (5.63 mmol) and 0.80 g of potassium carbonate (5.79 mmol) are mixed in 15 ml of methanol. The suspension is heated under reflux for 2 hours. The methanol is separated off, the residue is taken up in a saturated aqueous solution of sodium chloride and the mixture is extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and then concentrated under vacuum. The title product is isolated by chromatography on a silica column (eluent: hexane/ethyl acetate; 50:50). 1.14 g of a yellow oil are obtained.

1. temperatureThe suspension is heated
2. temperatureunder reflux for 2 hours
3. customThe methanol is separated off
4. extractionthe mixture is extracted with ethyl acetate
5. dry with materialThe organic phase is dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated under vacuum