Hydrogen Bromide → 2-Bromo-2'-methylacetophenone

HRID 376317ノート

反応式

HRID 376317 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[BrH:11].Br.[NH+]1C=CC=CC=1.O>C(O)(=O)C>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH2:9][Br:11]

参加物

6

反応物 4

HCID 260Hydrogen BromideHCID 962WaterHCID 113402-MethylacetophenoneHCID 21226041Pyridinium hydrobromide

生成物 1

HCID 124306762-Bromo-2'-methylacetophenone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 3 g of 2'-methylacetophenone in 60 ml of acetic acid was added successively 9.7 ml of 47% hydrobromic acid and 8.6 g of pyridinium hydrobromide perbromide, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water and a saturated sodium carbonate solution, and dried over anhydrous magnesium sulfate. The drying agent was removed by filtration, and the solvent was removed under reduced pressure to give 5.4 g of the title compound as a colorless oily material.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materiala saturated sodium carbonate solution, and dried over anhydrous magnesium sulfate
  4. customThe drying agent was removed by filtration
  5. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-f4fb5879f456462d90fc389bc2f9ab95
出典データセット
uspto-grants-2000_02
特許番号
US06020342

反応ノート

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