反应详情

温度

67.5 °C

To a mixture of 2-chloroacetic acid 2-methyl-1-(4-(methylsulfonyl)phenyl)propan-1-one ester (1.0 g, 3.13 mmol, prepared similarly to the compound of example 5, Step 1) and 5-chloro-2-pyridinol (0.41 g, 3.16 mmol) in CH3CN (20 mL) was added DBU (1.5 mL, 10.0 mmol) at r.t.. The mixture was stirred for 1 h, then heated at 65-70° C. for 3 h. The volatile solvents were removed in vacuo. The residue was chromatographed over silica gel and eluted with hexane:EtOAc (1:1) to yield a colorless oily residue which was swished in Et2O to provide the title compound as a white powder (230 mg).

1. customThe volatile solvents were removed in vacuo
2. customThe residue was chromatographed over silica gel
3. washeluted with hexane:EtOAc (1:1)
4. customto yield a colorless oily residue which