Sodium Hydroxide → HCID 178514392, compound

HRID 376391Notes

Reaction equation

HRID 376391 reaction equation
[NH2:1][N:2]=[CH:3][NH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([O:24]CC)=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[CH:7][CH:6]=1.[OH-].[Na+]>C(O)C>[NH2:1][N:2]=[CH:3][NH:4][C:5]1[CH:29]=[CH:28][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]3[O:20][CH:19]([CH2:21][C:22]([OH:24])=[O:23])[CH2:18][CH2:17][C:16]=3[CH:27]=2)=[O:10])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470592HCID 178470592, compound

Product 1

HCID 178514392HCID 178514392, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.08 g (0.2 mmol) of the ester from Example 64 were dissolved in 30 ml ethanol followed by addition of 0.4 ml aqueous 2 N sodium hydroxide solution. The mixture was stirred at room temperature for two days, and the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water, and the solution was neutralized with acetic acid, while the title acid precipitated. It was filtered with suction, washed with water, and dried in vacuo. Yield: 0.045 g (61%) of a beige crystalline solid, m.p. 258-260° C.

Workup

  1. concentrationthe mixture was concentrated to dryness under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. filtrationIt was filtered with suction
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-83a9195dd9a245188d9b09f0366813c0
Source dataset
uspto-grants-2000_02
Patent number
US06020362

Reaction notes

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