Hydrochloric Acid → HCID 69945809, compound

HRID 376398Notes

Reaction equation

HRID 376398 reaction equation
[NH2:1][N:2]=[CH:3][C:4]1[CH:26]=[CH:25][C:7]([C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]3[O:19][CH:18]([CH2:20][C:21]([OH:23])=[O:22])[CH2:17][CH2:16][C:15]=3[CH:24]=2)=[O:9])=[CH:6][CH:5]=1.[ClH:27].[CH3:28]O>>[ClH:27].[NH2:1][N:2]=[CH:3][C:4]1[CH:26]=[CH:25][C:7]([C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]3[O:19][CH:18]([CH2:20][C:21]([O:23][CH3:28])=[O:22])[CH2:17][CH2:16][C:15]=3[CH:24]=2)=[O:9])=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 69946925HCID 69946925, compound

Product 1

HCID 69945809HCID 69945809, compound

Procedure

A suspension of 0.35 g (1.0 mmol) of the acid from Example 48 in 20 ml methanol was cooled to 0° C. and saturated with gaseous hydrogen chloride. After 2 hours stirring it was concentrated under reduced pressure, and the remaining compound (343) was recrystallized from methanol/ether. Yield: 0.29 g (72%) of yellow crystals, m.p. 235-237° C.

Workup

  1. concentrationwas concentrated under reduced pressure
  2. customthe remaining compound (343) was recrystallized from methanol/ether

Sources & evidence

ORD record
ord-19245621fe77419bb816297178d3322a
Source dataset
uspto-grants-2000_02
Patent number
US06020362

Reaction notes

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