Ethanol → HCID 86753981, compound

HRID 376436Notes

Reaction equation

HRID 376436 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][C:13]([C:20]#[N:21])=[C:14]([OH:19])[CH2:15][CH2:16][C:17]#[CH:18])=[O:11])=[CH:5][CH:4]=1.C(O)C.O.[NH2:28][C@H:29]([C:35]([OH:37])=[O:36])[CH2:30][CH2:31][CH2:32][CH2:33][NH2:34]>O>[NH2:28][C@H:29]([C:35]([OH:37])=[O:36])[CH2:30][CH2:31][CH2:32][CH2:33][NH2:34].[F:1][C:2]([F:22])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([CH2:12][C:13]([C:20]#[N:21])=[C:14]([OH:19])[CH2:15][CH2:16][C:17]#[CH:18])=[O:11])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 702Ethanol2×HCID 16211825Lysine MonohydrateHCID 73605422HCID 73605422, compound

Product 1

HCID 86753981HCID 86753981, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

30 g (0.097 mol) of N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxy-hept-2-en-6-ynecarboxamide are dissolved in 1 l of water and 25 ml of ethanol together with 17.3 g (0.097 mol) of L-lysine hydrate, filtered and lyophilized. Adhering residual amounts of ethanol are removed by repeated freeze drying.

Workup

  1. customare removed
  2. customdrying

Sources & evidence

ORD record
ord-4d88d0854589486593b715016d6356a5
Source dataset
uspto-grants-2000_02
Patent number
US06020372

Reaction notes

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