Ethanol → HCID 70185499, compound

HRID 376437Notes

Reaction equation

HRID 376437 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:19])[C:11]([C:17]#[N:18])=[C:12]([CH:14]2[CH2:16][CH2:15]2)[OH:13])=[CH:5][CH:4]=1)#[N:2].C(O)C.O.[NH2:24][C@H:25]([C:31]([OH:33])=[O:32])[CH2:26][CH2:27][CH2:28][CH2:29][NH2:30]>O>[NH2:24][C@H:25]([C:31]([OH:33])=[O:32])[CH2:26][CH2:27][CH2:28][CH2:29][NH2:30].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:19])[C:11]([C:17]#[N:18])=[C:12]([CH:14]2[CH2:15][CH2:16]2)[OH:13])=[CH:7][CH:8]=1)#[N:2]

Participants

5

Reactant 3

HCID 702Ethanol2×HCID 16211825Lysine MonohydrateHCID 676596362-Cyano-N-(4-cyanophenyl)-3-cyclopropyl-3-hydroxyprop-2-enamide

Product 1

HCID 70185499HCID 70185499, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

15 g (0.054 mol) of 2-cyano-3-cyclopropyl-3-hydroxyacrylic acid (4-cyanophenyl)amide are dissolved in 900 ml of water and 10 ml of ethanol together with 9.6 g (0.054 mol) of L-lysine hydrate, filtered and lyophilized. Adhering residual amounts of ethanol are removed by drying under reduced pressure.

Workup

  1. customare removed
  2. customby drying under reduced pressure

Sources & evidence

ORD record
ord-18708390ef644009b0355454abf396ae
Source dataset
uspto-grants-2000_02
Patent number
US06020372

Reaction notes

Loading…