反应详情

温度

100 °C

4-Fluorotoluene (14 g) is added slowly with stirring to a solution of fuming nitric acid (18 g) and concentrated sulfuric acid (30 g) over 30 minutes and alternately warmed and cooled to keep the temperature between 40 and 50° C. This is followed by heating at 100° C. for 30 minutes more. The organic material is cooled and extracted with methylene chloride to give 16 g of 4-fluoro-2-nitrotoluene.

1. temperaturealternately warmed
2. temperaturecooled
3. customthe temperature between 40 and 50° C
4. temperatureThe organic material is cooled
5. extractionextracted with methylene chloride