Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | p-Fluorotoluene | HCID 9603 | — |
| Product | 4-Fluoro-2-nitrotoluene | HCID 67965 | 81.1% |
Reaction Steps
4-Fluorotoluene (14 g) is added slowly with stirring to a solution of fuming nitric acid (18 g) and concentrated sulfuric acid (30 g) over 30 minutes and alternately warmed and cooled to keep the temperature between 40 and 50° C. This is followed by heating at 100° C. for 30 minutes more. The organic material is cooled and extracted with methylene chloride to give 16 g of 4-fluoro-2-nitrotoluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06020379 |
|---|
| Source dataset | uspto-grants-2000_02 |
|---|
| ORD ID | ord-2ee120e614af43e9892804db6475cb6a |
|---|
| Source note | uspto-grants-2000_02 |
|---|
