HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 5'-Fluoro-2'-Formyl-4-Methylthiobiphenyl | HCID 19361946 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Catalyst | Tetrabutylammonium hydrogen sulfate | HCID 94433 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl | HCID 19361941 | — |
Reaction Steps
5'-Fluoro-2'-formyl-4-methylthiobiphenyl (10 mmol) (Example 1E) in THF (20 ml) is charged dropwise with oxone® (6 mmol) and tetrabutylammonium hydrogensulfate (1 mmol) in water (15 ml). The mixture is stirred at room temperature for 1 hour. The suspension is poured into water (300 ml), the precipitate is filtered off, is washed with water and is dried in vacuo to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06020379 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-382c66dc8b9d4744a64ecbb415b1b451 |
| Source note | uspto-grants-2000_02 |