Trifluoroacetic acid → HCID 86753786, compound

HRID 376539Notes

Reaction equation

HRID 376539 reaction equation
C([O:5][C:6](=[O:21])[C:7]1[CH:12]=[CH:11][C:10]([C:13]([NH2:20])=[N:14][O:15][C:16]([O:18][CH3:19])=[O:17])=[CH:9][CH:8]=1)(C)(C)C.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[NH2:20][C:13](=[N:14][O:15][C:16]([O:18][CH3:19])=[O:17])[C:10]1[CH:9]=[CH:8][C:7]([C:6]([OH:21])=[O:5])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53801236HCID 53801236, compound

Product 1

HCID 86753786HCID 86753786, compound

Procedure

In 4.0 ml of trifluoroacetic acid was dissolved 1.0 g of 4-(amino-methoxycarbonyloxyiminomethyl)benzoic acid t-butyl ester. The solution was stirred for one hour at room temperature. The reaction mixture was concentrated under reduced pressure. The concentrate was subjected to azeotropic distillation with toluene to afford 0.80 g of the titled compound as a colorless amorphous powdery product.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. distillationThe concentrate was subjected to azeotropic distillation with toluene

Sources & evidence

ORD record
ord-cf8cc439dd1f49adb5721067f448296c
Source dataset
uspto-grants-2000_02
Patent number
US06020334

Reaction notes

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