Diethylamine → N,N-Diethyl-2,5-bis(trifluoromethyl)benzamide

HRID 376644Notes

Reaction equation

HRID 376644 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:4]=1[C:5](Cl)=[O:6].[CH2:18]([NH:20][CH2:21][CH3:22])[CH3:19]>>[CH2:18]([N:20]([CH2:21][CH3:22])[C:5](=[O:6])[C:4]1[CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=[CH:11][C:3]=1[C:2]([F:17])([F:16])[F:1])[CH3:19]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 27378122,5-Bis(trifluoromethyl)benzoyl chloride

Product 1

HCID 15832108N,N-Diethyl-2,5-bis(trifluoromethyl)benzamide

Procedure

N,N-Diethyl-2,5-bis(trifluoromethyl)benzamide was prepared from 2,5-bis(trifluoromethyl)benzoyl chloride and diethylamine according to General Method E1. The desired intermediate was isolated in quantitative yield (11.3 g) without additional purification.

Sources & evidence

ORD record
ord-1a779ae58bb44501ad3e0c93506808b1
Source dataset
uspto-grants-2000_02
Patent number
USRE036562

Reaction notes

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