Ethylamine → HCID 17683089, compound

HRID 376688Notes

Reaction equation

HRID 376688 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=O.[CH2:14]([NH2:16])[CH3:15]>>[CH2:14]([NH:16][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([C:2]([F:1])([F:13])[F:12])[CH:4]=1)[CH3:15]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 99633-(Trifluoromethyl)benzoic acid

Product 1

HCID 17683089HCID 17683089, compoundYield 19%

Procedure

3-Trifluoromethylbenzoic acid was converted to the acid chloride by the procedure of example b. The acid chloride was reacted with 70% aq ethylamine using General Method E1 to afford the title compound Purification by recrystallization from hexanes gave 2.24 g of N-ethyl-3-(trifluoromethyl)benzamide as a white needles in 19% yield. m.p. 98°-99° C.

Workup

  1. customto afford
  2. customthe title compound Purification
  3. customby recrystallization from hexanes

Sources & evidence

ORD record
ord-6de2b85fd29e48d6aca82a77c675336a
Source dataset
uspto-grants-2000_02
Patent number
USRE036562

Reaction notes

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