HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 5-Bromo-2-(6-octyloxypyridin-3-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2,5-Dibromopyrimidine | HCID 10955588 | — |
| Reactant | (6-Butoxypyridin-3-yl)boronic acid | HCID 45116227 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Bromo-2-(6-octyloxypyridin-3-yl)pyrimidine | HCID 19359091 | 75.9% |
Reaction Steps
A reaction of 115 mmol of 2,5-dibromopyrimidine, 115 mmol of 2-butoxypyrdine-5-boronic acid, 230 mmol of sodium carbonate and 1.2 mmol of tetrakis(triphenylphosphine)palladium(0) in 280 ml of toluene, 140 ml of ethanol and 140 ml of water is carried out analogously to the procedure indicated for precursor 3. Corresponding purification gives 15.9 g (38%) of a colorless solid, m.p. 99-101 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022492 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-443f576be76647e889e72cdc00ae6c8e |
| Source note | uspto-grants-2000_02 |