5-Bromo-2-chloropyrimidine → 2-Chloro-5-(6-hexyloxypyridin-3-yl)pyrimidine

HRID 376758Notes

Reaction equation

HRID 376758 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH2:9]([O:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][N:17]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]>>[Cl:8][C:5]1[N:4]=[CH:3][C:2]([C:19]2[CH:18]=[N:17][C:16]([O:15][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[CH:21][CH:20]=2)=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 221125716-Hexyloxypyridine-3-boronic acid

Product 1

HCID 193591062-Chloro-5-(6-hexyloxypyridin-3-yl)pyrimidine

Procedure

A reaction of 5-bromo-2-chloropyrimidine and 2-hexyloxypyridine-5-boronic acid is carried out analogously to the procedure indicated for precursor 3. Corresponding purification gives a colorless solid.

Workup

  1. custompurification
  2. customgives a colorless solid

Sources & evidence

ORD record
ord-0cc33b8b355b461daae7c2cc00609d0d
Source dataset
uspto-grants-2000_02
Patent number
US06022492

Reaction notes

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