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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 376766Generated: October 31, 2026

2-(4-Benzyloxy-2,3-difluorophenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine → 2-(2,3-Difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine

https://huagongshe.com/reaction/376766

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Benzyloxy-2,3-difluorophenyl)-5-(6-octyloxypyridin-3-yl)pyrimidineHCID 17869401—
SolventTetrahydrofuranHCID 8028—
Product2-(2,3-Difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidineHCID 13559744594.4%

Reaction Steps

The hydrogenation of 21 mmol of 2-(4-benzyloxy-2,3-difluorophenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine in 200 ml of THF is carried out analogously to the procedure indicated for precursor 14, giving 8.2 g (93%) of a colorless solid, m.p. 130-132° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06022492
Source datasetuspto-grants-2000_02
ORD IDord-6af3060794e24cd5bf28505a71e3a11a
Source noteuspto-grants-2000_02