1-Bromohexane → 2-(2,3-Difluoro-4-hexyloxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine

HRID 376770Notes

Reaction equation

HRID 376770 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([OH:9])[CH:5]=[CH:4][C:3]=1[C:10]1[N:15]=[CH:14][C:13]([C:16]2[CH:17]=[N:18][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:20][CH:21]=2)=[CH:12][N:11]=1.Br[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>>[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:5]=[CH:4][C:3]=1[C:10]1[N:15]=[CH:14][C:13]([C:16]2[CH:17]=[N:18][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[CH:20][CH:21]=2)=[CH:12][N:11]=1

Participants

3

Reactant 2

HCID 81011-BromohexaneHCID 1355974452-(2,3-Difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine

Product 1

HCID 193590972-(2,3-Difluoro-4-hexyloxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidineYield 73%

Procedure

The etherification of 2.4 mmol of 2-(2,3-difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine using 2.7 mmol of 1-bromohexane is carried out analogously to the procedure indicated in Example 3. Corresponding purification gives 0.88 g (73%) of colorless crystals, X 81.5 S3 75.5 SC 165.6 SA 174 I.

Workup

  1. custompurification

Sources & evidence

ORD record
ord-73d1b77215dc4bc38d1ac534f8276ef5
Source dataset
uspto-grants-2000_02
Patent number
US06022492

Reaction notes

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