HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromohexane → 2-(2,3-Difluoro-4-hexyloxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromohexane | HCID 8101 | — |
| Reactant | 2-(2,3-Difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine | HCID 135597445 | — |
| Product | 2-(2,3-Difluoro-4-hexyloxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine | HCID 19359097 | 73% |
Reaction Steps
The etherification of 2.4 mmol of 2-(2,3-difluoro-4-hydroxyphenyl)-5-(6-octyloxypyridin-3-yl)pyrimidine using 2.7 mmol of 1-bromohexane is carried out analogously to the procedure indicated in Example 3. Corresponding purification gives 0.88 g (73%) of colorless crystals, X 81.5 S3 75.5 SC 165.6 SA 174 I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022492 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-73d1b77215dc4bc38d1ac534f8276ef5 |
| Source note | uspto-grants-2000_02 |