Guanidine → HCID 15289639, Verbindung

HRID 376862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 376862
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[O:14][C:15]1[CH:20]=[CH:19][C:18](=[O:21])[NH:17][N:16]=1)[C:8](O)=[O:9])(=[O:4])=[O:3].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:34][C:35]([NH2:37])=[NH:36]>C1COCC1>[NH2:36][C:35]([NH2:37])=[N:34][C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:13]([O:14][C:15]2[CH:20]=[CH:19][C:18](=[O:21])[NH:17][N:16]=2)=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH:6]=1

Komponenten

5

Edukt 3

HCID 3520GuanidineHCID 682631,1'-CarbonyldiimidazoleHCID 15289638HCID 15289638, Verbindung

Produkt 1

HCID 15289639HCID 15289639, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 540 mg of 3-methylsulfonyl-4-(1,6-dihydro-6-oxo-3-pyridazinyloxy)benzoic acid [obtainable by reacting 3-methylsulfonyl-4-chlorobenzoic acid with 3-trimethylsilyl-oxy-6-oxo-1,6-dihydropyridazine] and 300 mg of carbonyldiimidazole in 15 ml of THF is stirred at room temperature for 2 hours, and 383 mg of guanidine are then added to it. This mixture is then stirred for a further two hours. After the customary working-up, N-diaminomethylene-3-methylsulfonyl-4-(1,6-dihydro-6-oxo-3-pyridazinyloxy)benzamide is obtained, m.p. 268-270°.

Quellen und Nachweise

ORD-Eintrag
ord-0ebbee2040f54acf9dc814748fecb0ce
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06022883

Notizen zur Reaktion

Wird geladen…