Guanidine → HCID 15289639, compound

Participants

Reaction Steps

A solution of 540 mg of 3-methylsulfonyl-4-(1,6-dihydro-6-oxo-3-pyridazinyloxy)benzoic acid [obtainable by reacting 3-methylsulfonyl-4-chlorobenzoic acid with 3-trimethylsilyl-oxy-6-oxo-1,6-dihydropyridazine] and 300 mg of carbonyldiimidazole in 15 ml of THF is stirred at room temperature for 2 hours, and 383 mg of guanidine are then added to it. This mixture is then stirred for a further two hours. After the customary working-up, N-diaminomethylene-3-methylsulfonyl-4-(1,6-dihydro-6-oxo-3-pyridazinyloxy)benzamide is obtained, m.p. 268-270°.

Provenance & Evidence