HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine → N-diaminomethylene-3-methylsulfonyl-4-(6-methyl-3-pyridyloxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine | HCID 3520 | — |
| Reactant | 4-Chloro-3-methanesulfonylbenzoic acid | HCID 182670 | — |
| Reactant | 3-Trimethylsilyloxy-6-methylpyridine | HCID 597272 | — |
| Reactant | Methyl 3-methylsulfonyl-4-(6-methyl-3-pyridyloxy)benzoate | HCID 19360282 | — |
| Reactant | Methyl iodide potassium carbonate | HCID 86747754 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-diaminomethylene-3-methylsulfonyl-4-(6-methyl-3-pyridyloxy)benzamide | HCID 19360327 | — |
Reaction Steps
In analogy with Example 2, reacting guanidine with methyl 3-methylsulfonyl-4-(6-methyl-3-pyridyloxy)benzoate [obtainable by reacting 3-methylsulfonyl-4-chlorobenzoic acid with 6-methyl-3-trimethylsilyloxypyridine and subsequently esterifying the product with methyl iodide/K2CO3 in DMF] gives N-diaminomethylene-3-methylsulfonyl-4-(6-methyl-3-pyridyloxy)benzamide, m.p. 197-199°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022883 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-8a308bace9b54b38b6f6379e4235840f |
| Source note | uspto-grants-2000_02 |