反应详情

Safrole oxide was prepared by stirring a solution of safrole (1.48 mL, 10 mmol) and m-chloroperoxybenzoic acid (2.70 g, 11 mmol) in methylene dichloride (25 mL) overnight. The reaction was quenched by pouring into water (50 mL). The aqueous was extracted with ether (3×25 mL). The organic layers were combined and washed with 10% aqueous sodium sulfate (2×25 mL), saturated aqueous sodium bicarbonate (3×25 mL), and brine (25 mL). The organic phase was dried over magnesium sulfate and the solvents were removed in vacuo. The resulting yellow oil was used without further purification.

1. customThe reaction was quenched
2. additionby pouring into water (50 mL)
3. extractionThe aqueous was extracted with ether (3×25 mL)
4. washwashed with 10% aqueous sodium sulfate (2×25 mL), saturated aqueous sodium bicarbonate (3×25 mL), and brine (25 mL)
5. dry with materialThe organic phase was dried over magnesium sulfate
6. customthe solvents were removed in vacuo
7. customThe resulting yellow oil was used without further purification