HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thioanisole → 1-Propanone, 2-bromo-2-methyl-1-[4-(methylthio)phenyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thioanisole | HCID 7520 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | Bisphenol A diglycidyl ether diacrylate | HCID 92212 | — |
| Reactant | 2-Methyl-1-[4-(methylthio)phenyl]-1-propanone | HCID 852539 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Propanone, 2-bromo-2-methyl-1-[4-(methylthio)phenyl]- | HCID 11459984 | — |
Reaction Steps
149.2 g (0.77 mol) of 2-methyl-1-[4-(methylthio)-phenyl]-propan-1-one, prepared by acylating thioanisol (as is described in EP-A-3002), are dissolved in 770 ml of methylene chloride. 0.2 ml of chlorosulfonic acid and 123.0 g (0.77 mol) of bromine are added dropwise slowly to this solution, with cooling, at room temperature. After stirring overnight, the solution is concentrated and is then reacted further as described below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06022906 |
| Source dataset | uspto-grants-2000_02 |
| ORD ID | ord-e77ae36f6500489489741b2cc5e65a3d |
| Source note | uspto-grants-2000_02 |