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HRID376978

反应详情

EQUATION

反应方程式

HRID 376978 的结构方程式

REACTANTS

反应物

5
结构：CSc1ccccc1
HCID7520

Benzene, (methylthio)-

C7H8S

结构：BrBr
HCID24408

Bromine

Br2

结构：O=S(=O)(O)Cl
HCID24638

Chlorosulfuric acid

HClO3S

结构：C=CC(=O)OCC(O)COc1ccc(C(C)(C)c2ccc(OCC(O)COC(=O)C=C)cc2)cc1
HCID92212

2,2-Bis[4-(3-acryloyloxy-2-hydroxypropoxy)phenyl]propane

C27H32O8

结构：CSc1ccc(C(=O)C(C)C)cc1
HCID852539

2-Methyl-1-[4-(methylthio)phenyl]-1-propanone

C11H14OS

PRODUCTS

生成物

1
结构：CSc1ccc(C(=O)C(C)(C)Br)cc1
HCID11459984

1-Propanone, 2-bromo-2-methyl-1-[4-(methylthio)phenyl]-

C11H13BrOS

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

149.2 g (0.77 mol) of 2-methyl-1-[4-(methylthio)-phenyl]-propan-1-one, prepared by acylating thioanisol (as is described in EP-A-3002), are dissolved in 770 ml of methylene chloride. 0.2 ml of chlorosulfonic acid and 123.0 g (0.77 mol) of bromine are added dropwise slowly to this solution, with cooling, at room temperature. After stirring overnight, the solution is concentrated and is then reacted further as described below.

WORKUP

后处理

  1. concentrationthe solution is concentrated
  2. customis then reacted further